Ancestral origami

To fold life’s proteins:

Ancestral origami

around hockey pucks.

 

The basic way DNA is stored within cells is remarkably conserved suggesting a deep ancestral origin. Mattiroli et al (2017) have revealed that the way DNA is folded in eukaryotes (a domain containing animals, plants, fungi and protists) is very similar to the way its folded in archaea, a domain of single-celled microorganisms containing some of the oldest forms of life.

In both eukaryotes and archaea DNA is wrapped around proteins called histones creating the same DNA geometry. This suggests that eukaryote DNA folding method is ancestral, although a key difference is that in eukaryotes DNA is wrapped around bundles of 8 histones (sometimes referred to as a ‘hockey puck’) whilst in archaea its just wrapped around individual histones.

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